I am interested in translational research with the goals of linking understanding of the mechanisms of serious mental illness to new approaches to treating patients. Current projects focus on abnormalities of synapses in schizophrenia and aging, studies of response to antipsychotic drug treatment in patients, and investigating the overlap of mental illness, addiction, and viral infection in people living in single room occupancy hotels. I am also pursuing the development of novel treatments through investigating protein-protein interactions occurring at synapses. Research techniques used include biochemical studies of postmortem brain tissue, brain imaging with MRI, and neurocognitive assessment.
Barakauskas VE, Beasley CL, Barr AM, Ypsilanti AR, Li H-Y, Thornton AE, Wong H, Rosoklija G, Mann JJ, Mancevski B, Jakovski Z, Davceva N, Ilievski B, Dwork AJ, Falkai P, Honer WG (2010) A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia.Neuropsychopharmacol 35:1226-1238.
Chen EYH, Hui CLM, Lam MML, Chiu CPY, Law CW, Chung DWS, Tso S, Pang EPF, Chan KT, Wong WC, Mo FYM, Chan KPM, Yao TJ, Hung SF, Honer WG(2010) Maintenance therapy in patients with remitted first-episode psychosis following one year of treatment: a randomized controlled study comparing discontinuation versus quetiapine Brit Med J (in press)
Pajonk F-G, Wobrock T, Gruber O, Scherk H, Berner D, Kaizl I, Kierer A, Müller S, Oest M, Meyer T, Backens M, Schneider-Axmann T, Thornton AE, Honer WG, Falkai P (2010) Hippocampal plasticity in response to exercise in schizophrenia.Arch Gen Psychiatry 67:133-143.
Honer WG, Procyshyn RM, Chen EYH, MacEwan GW, Barr AM (2009) A translational research approach to poor treatment response in schizophrenia: clozapine-antipsychotic polypharmacy. J Psychiatry Neurosci 34:433-442
Honer WG, Thornton AE, Chen EYH, Chan RCK, Wong JOY, Bergmann A, Falkai P, Pomarol-Clotet E, McKenna PJ, Stip E, Williams R, MacEwan GW, Wasan K, Procyshyn R (2006) Clozapine alone versus clozapine and risperidone with refractory schizophrenia. New Engl J Med 354:472-482.