Please contact Dr. Yatham for information on specific research projects.
Yatham LN, Kennedy SH, O'Donovan C, Parikh SV, McIntyre R, Sharma V, Beaulieu S: CANMAT Guidelines for Management of patients with bipolar disorder: An Update for 2007. Bipolar Disorders,8 (6), 721-739, 2006
Yatham LN, Goldstein J, Vieta E, Bowden CL, Grunze H, Post RM, Suppes T, Calabrese JR: Atypical Antipsychotics in Bipolar Depression: Potential Mechanisms of Action. Journal of Clinical Psychiatry,66; suppl 15; 40-48:2005
Yatham LN, Paulsson B, Mullen J, Vagero M: Quetiapine Versus Placebo in Combination With Lithium or Divalproex for the Treatment of Bipolar Mania. J Clin Psychopharmacology, 24(6):599-606;2004
Yatham LN, Liddle PF, Lam RW, Shia I-S, Lane C, Stoessl J, Sossi V, Ruth TJ: PET studies of dopamine D2 receptors in Neuroleptic and mood stabilizer naïve first episode manic patients before and after valproate. American Journal of Psychiatry, 159; 1718-1723; 2002
Yatham LN, Liddle PF, Shiah I-S, Lam RW, Ngan E, Scarrow G, Imperial M, Stoessl J, Sossi V, Ruth TJ: PET studies of flourodopa uptake in neuroleptic and mood stabilizer naïve first episode manic patients before and after valproate. American Journal of Psychiatry;159(5):768-774. 2002
Yatham LN, Liddle PF, Shiah IS, Lam RW, Adam MJ, Zis AP, Ruth TJ: Effects of rapid tryptophan depletion on brain serotonin 2 receptor binding in healthy human subjects: a positron emission tomography study with fluorine 18-labeled setoperone. British Journal of Psychiatry, 178: 448-453, 2001
Yatham LN, Liddle PF, Shiah IS, Scarrow G, Lam RW, Adam MJ, Zis AP, Ruth TJ: Brain 5-HT2 receptor density in patients with major depression: A PET study. Archives of General Psychiatry, 57 (9): 850-858,2000
Yatham LN, Liddle PF, Dennie J, Shiah IS, Adam MJ, Lane C, Lam RW, Ruth TJ: Effects of desipramine treatment on brain 5-HT2 receptors in patients with major depression: a positron emission tomography study with [18F]setoperone. Archives of General Psychiatry,56 (8): 705-711, 1999.
Yatham LN, Grossman F, Augusymus I, Vieta E, Ravindran R: An International Double blind randomized placebo controlled trial of risperidone vs placebo add-on to mood stabilizers in acute mania. British Journal of Psychiatry,182:141-147: 2003.
Lakshmi N. Yatham, MBBS, FRCPC, MRCPsych (UK), is Professor of Psychiatry and Associate Head of Research and International Affairs in the Department of Psychiatry at the University of British Columbia in Vancouver. His major areas of research interest include neurobiology and treatment of bipolar disorder and major depression. Dr. Yatham was a recipient of the Michael Smith Foundation Senior Scholar Award, and his work has been funded by a number of peer-reviewed funding agencies such as the Canadian Institutes of Health Research (CIHR), Canadian Psychiatric Research Foundation, Stanley Foundation, and National Alliance for Research on Schizophrenia and Depression, USA. . Dr. Yatham leads a Canadian consortium on bipolar disorder, which is currently pursuing testing of new treatments for bipolar disorder using pragmatic and controlled trials with substantial funding from CIHR.
Dr. Yatham co-led the development of Canadian guidelines for treatment of bipolar disorder in 1997 and his group recently revised the guidelines for 2005 and these were published with International Commentaries in Bipolar Disorders Journal in June. He is Chair of the bipolar group of the Canadian Network for Mood and Anxiety Treatments (CANMAT), and is actively involved at a national and international level in continuing medical education and public education on diagnosis and treatment of bipolar disorder for psychiatrists, family physicians, and the general public. Dr. Yatham is currently the President for the International Society for Bipolar Disorders and he is on the editorial boards of a number of journals including Bipolar Disorders, Brain Pharmacology, Human Psychopharmacology, Quarterly Journal of Mental Health etc. He has published over 140 papers in peer-reviewed international journals and presented his research work at numerous international conferences.