Plasticity of synaptic transmission – mechanisms and age-related aspects.
Recent interests include the examination of mechanisms involved in the plasticity of GABA-ergic synaptic transmission in the mammalian central nervous system. We are also analyzing age-relatedness of this plasticity.
Dr. Sastry’s research has been funded by grants from the National Institutes of Health, USA.
M. Ouardouz and B. R. Sastry. Mechanisms underlying LTP of inhibitory synaptic transmission in the deep cerebellar nuclei. J. Neurophysiol. 84: 1414-1421, 2000.
W. Morishita and B. R. Sastry. Postsynaptic mechanisms underlying long-term depression of GABAergic transmission in neurons of the deep cerebellar nuclei. J. Neurophysiol. 76: 59-68, 1996.
T. Shew, S. Yip and B. R. Sastry. Mechanisms involved in tetanus-induced potentiation of fast IPSCs in rat hippocampal neurons. J. Neurophysiol. 83: 3388-3401, 2000.
B. R. Sastry and L. S. Bhagavatula. Quantal release of transmitter at a central synapse. Neuroscience 75: 987-992, 1996.
B. R. Sastry, J. W. Goh and A. Auyeung. Associative induction of post-tetanic and long-term potentiation in CA1 neurons of rat hippocampus. Science 232: 988-990, 1986.
The Vancouver Biomedical Research Foundation (VBHRF)
The foundation is dedicated to pursuing as well as organizing discussions on research in biomedical and health fields, and in enhancing public awareness of science. B. R. Sastry is the founder and the current director of this foundation. VBHRF has organized three international symposia in Vancouver during the last three years. A number of internationally well-known scientists participated in these symposia.
Three post-doctoral positions are available in the near future in Dr. Sastry’s laboratory. Those with Ph.D.’s in neuroscience having expertise with the patch-clamp recordings from mammalian central neurons need apply.