Neat!

Hakima Moukhles

Assistant Professor
Department of Cellular and Physiological Sciences


Email: haki...@ubc.ca
Phone: 604 822- 7882

Web pages: Lab webpage

 

Education

  • Postdocs:  McGill University and University of Montreal
  • PhD:  University of Aix Marseille II
  • MSc:  University of Aix Marseille II
  • BSc:  Faculty Mohammed V

Keywords

  • Dystroglycan
  • Glial cells

Research Interests

Researching the role of dystroglycan, a protein associated with several forms of muscular dystrophy, in the central nervous system. Molecular mechanisms underlying the dystroglycan-mediated targeting and polarization of proteins in glial cells.


Selected Publications

Noël G, Stevenson S and Moukhles H. A High Throughput Screen Identifies Chemical Modulators of the Laminin-induced Clustering of Dystroglycan and Aquaporin-4 in Primary Astrocyte Cultures. (Accepted for publication in PLoS ONE).

Lui L, Levinson JN, Noël G, Handrigan GR, Richman JM, El-Husseini A and Moukhles H. 2010. Synaptic Localization of Neuroligin 2 in the Rodent Retina: a Comparative Study with the Dystroglycan-Containing Complex. J Neuroscience Research. 88:837–849.

Noël G, Tham D and Moukhles H. 2009. Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes. Journal of Biological Chemistry. 284(29):19694-704.

Rurak J, Noël G, Lui L, Joshi B and Moukhles H. 2007. Distribution of potassium ion and water permeable channels at perivascular glia in brain and retina of the Largemyd mouse. Journal of Neurochemistry. 103 (5):1940–1953.

Noël G, Belda M, Guadagno E, Micoud J, Klöcker N, Moukhles H. 2005. Dystroglycan and Kir4.1 coclustering in retinal Müller glia is regulated by laminin-1 and requires the PDZ-ligand domain of Kir4.1.J. Neurochem. 94(3):691-702.

Guadagno E and Moukhles H. 2004. Laminin-induced aggregation of the inwardly rectifying potassium channel, Kir4.1, and the water permeable channel, AQP4, via a dystroglycan-containing complex in astrocytes. Glia. 47 (2):138-49

Côté PD, Moukhles H, Carbonetto S. 2002. Dystroglycan is not required for localization of dystrophin, syntrophin, and neuronal nitric-oxide synthase at the sarcolemma but regulates integrin alpha 7B expression and caveolin-3 distribution. J. Biol. Chem. 277(7):4672-9.

Moukhles H, Carbonetto S. 2001. Dystroglycan contributes to the formation of multiple dystrophin-like complexes in brain. J. Neurochem. 78(4):824-34.

Moukhles H, Roque R, Carbonetto S. 2000. alpha-dystroglycan isoforms are differentially distributed in adult rat retina. J. Comp. Neurol. 420(2):182-94.

Leschziner A, Moukhles H, Lindenbaum M, Gee SH, Butterworth J, Campbell KP, Carbonetto S. 2000. Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle. J. Neurochem. 74(1):70-80.

Côté PD, Moukhles H, Lindenbaum M, Carbonetto S. 1999. Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses. Nat Genet. 23(3):338-42.

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