Neat!

Doris J Doudet

Professor, Medicine & Neurology, UBC
Adjunct Professor, University of Aarhus, Denmark
Member, Pacific Parkinson Research Center
Member, Brain Research Center


Email: Ddou...@mail.ubc.ca
Phone: 604 822-7163

Web page: N/A

 

Education

  • Ph.D.  Neurosciences, University Bordeaux I, France, 1983
  • Ph.D.  Human Neurophysiology, University Bordeaux II, France, 1986
  • Fogarthy Fellow, National Institute of Health, Bethesda, MD, USA, 1986-1988
  • Visiting Scientist, Johns Hopkins Medical School, Dept. Neurology, Baltimore, MD 1987
  • Visiting Scientist, National Institute of Mental Health, Clinical Brain Imaging, Bethesda, MD, USA, 1988-1993

Keywords

  • PET
  • Neuroimaging
  • Parkinson’s disease
  • Mood Disorders
  • Stimulation Therapies
  • Monoaminergic Systems

Research Interests

I use neuroimaging methods such as PET and MR to 1) understand the effects of stimulation therapies such as TMS on brain function and 2) understand the role and function of dopamine, serotonin and noradrenaline in neurodegenerative diseases such as Parkinson’s and mood disorders.

For a number of years, I have taken advantage of the possibility to use positron emission tomography (PET) to study in vivo, longitudinally, compensatory changes in the monoaminergic system induced by aging or lesion of the DA nigro-striatal system as in Parkinson’s Disease (PD) or depression in rodents, primates and porcines.  These studies are performed in collaboration with the UBC/TRIUMF PET program and use a number of radioactive tracers specific for DA, serotonin and noradrenalin.  The current main aspects are to investigate the effects of experimental therapies for PD and depression on the function of the monoamine systems in acute and chronic conditions and to develop methods of scanning applicable to human to study specific aspects of receptors and transporters function.

The methodologies employed cover both behavioral assessment, binding assays using autoradiographic techniques with a phosphor imaging device, microdialysis and immunostains in addition of PET imaging with current state of the art tomograph for human (HRRT) and rodents (microPET R4).  

Selected Publications

Strome EM, Wheeler GH, Higley D, Loriaux DL, Suomi SJ, Doudet DJ “Intracerebroventricular corticotrophin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in non-human primates” PNAS 99:15749-15754 (2002)

McGeer P.L., Schwab C., Parent A., Doudet D.J., “Presence of reactive microglia in monkey substantia nigra years after MPTP administration” Ann. Neurol., 54:599-604 (2003)

Doudet DJ., Allen R., Honey C., Schweikert A., Cornfeldt M. “In vivo evaluation of retinal pigment epithelial cell transplant by PET “ Exp. Neurol. 189:361-368 (2004)

Strome E.M., Jivan S., Doudet DJ. “Quantitative in vitro phosphor imaging using [3H] and [18F] radioligands: effects of chronic desipramine treatment on serotonin 5HT2 receptors” J. Neurosci.Methods 141:143-154 (2005)

Strome EM, Clark CM, Zis AP, Doudet DJ. “Electroconvulsive shock decreases binding to 5-HT2 receptors in non-human primates: an in vivo PET study with [18f]setoperone1" Biological Psychiatry,  57:1004-1010 (2005)

Doudet DJ, Rosa-Neto P, Ruth TJ, Jivan S., Cumming P. “Mapping of markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: A multi-tracer PET study” NeuroImage, 30: 2-35 (2006)

Strome E, Cepeda I, Sossi V, Doudet DJ “Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal pet compared to behavioral assesment and autoradiography” MIB 8:292-299 (2006)

Strome EM, Zis AP, Doudet DJ “Electroconvulsive shock enhances striatal D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats” J. Psychiat. Neurosci. 32:193-202 (2007)

Cepeda I, Flores J, Cornfeldt M, O’Kusky J, Doudet DJ.  “Human Retinal Pigment Epithelial Cell Implants Ameliorate Motor Deficits in Two Rat Models of Parkinson’s Disease” J. Neuropath. Exp. Neurol. 66:576-584 (2007)

 Flores J, Cepeda I, Cornfeldt M, O’Kusky J, Doudet DJ. Characterization of Long Term Implants of Human Retinal Pigment Epithelial Cells Attached to Gelatin Microcarriers in a Rat Model of Parkinson’s Disease” J. Neuropath. Exp. Neurol. 66:585-595 (2007)

Ostergaard SD, Olsen AK, Gramsbergen JB, Minuzzi L, Pedersen K, Jensen SB, Doudet DJ, Cumming P.  MDMA-evoked changes in the binding of dopamine D2 receptor ligands in the striatum of rats with unilateral serotonin depletion.  Synapse 64:70-82 (2010)

Linnet J, Moller A, Peterson E, Gjedde A, Doudet DJ.  Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling.  Addiction  106:383-390 (2010)

Landau A, Chakaravarty M, Clark C, Jivan S, Zis A, Doudet DJ.  Electroconvulsive therapy alter dopamine signalling in the striatum of non human primates. Neuropsychopharmacol. 36:511-518 (2011)

Ma Y, Peng S, Spetsieris PG, Sossi V, Eidelberg D, Doudet DJ. Abnormal metabolic brain networks in a non human primate model of parkinsonism. J.Cereb.Blood Flow Metab. 32:633-642 (2012)

Nahimi A, Holtzermann M, Landau AM, Simonsen M, Jakobsen S, Olsen AK, Vang K, Moller A, Wegener G, Gjedde A,  Doudet DJ. Serotoninergic modulation of receptor occupancy in rats treated with L-dopa after unilateral 6OHDA lesioning.  J.Neurochem 120:806-817 (2012)

Sossi V, Dinelle K, Jivan S, Fisher K, Holden JE, Doudet DJ. In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson’s disease using 11C-methylphenidate PET.  J.Nuc. Med.  53:813-822 (2012)

Mackey S, Jing Y, Flores J, Dinelle K, Doudet DJ. Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, PET, immunohistochemistry. Exp Neurol. (2013) 247:19-24

Alstrup AKO*, Landau AM*,  Holden JE, Jakobsen S, Schacht SA, Audrain H, Wegener G, Hansen AK, Gjedde A and Doudet DJ.  Effects of anesthesia and species on the uptake or binding of radioligands in vivo.  Biomed Research International  2013  PMID: 24083242

Landau  AM, Dyve S, Jakobsen S, Alstrup AKO, Audrain H, Gjedde A, Doudet DJ. Acute vagal nerve stimulation decreases alpha2-adrenoceptor binding in minipig brain. Brain Stimulation (2015) 8:702-202. PMID:25758422

Landau Am, Phan JA, Iversen P, Simonsen M, Wegener G, Jakobsen S, Doudet DJ. Decreased alpha2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression.  Neuropharmacol. (2015) 91: 97-102 PMID: 25576372

Lillethorup T, Iversen P, Fontain J, Wegeners G, Doudet DJ, Landau AM Electroconvulsive Shocks Decrease α2-Adrenoceptor Binding in the Flinders Rat Model of Depression. Eur. Neuropsychopharmacol. (2015) 25:404-412 . PMID:25604421

Bannon D, Landau AM, Doudet DJ. How relevant are imaging findings in animal models of movement disorders to human disease?  Current Neurology and Neuroscience Reports (2015) 15(8):571 PMID: 26092313

Other

    Recipient of:

  • Roche Neurological Prize, 1986
  • NARSAD Young Investigator Award, 1998
  • Martin Hoffman Award for Excellence in Research, 2003

 

 

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