The biological basis of mental illness is not fully understood. The main aim of my research is to identify neuropathological features associated with schizophrenia, bipolar disorder and major depressive disorder using post-mortem human brain tissue. Current projects focus on white matter pathology, brain inflammation and glial cells. In addition, I am interested in the effects of antipsychotic medications on the brain, including alterations in lipid levels and damage related to oxidative stress.
Barakauskas VE, Ypsilanti AR, Barr AM, Innis SM, Honer WG, Beasley CL. Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34(4):669-73.
Beasley CL, Dwork AJ, Rosoklija G, Mann JJ, Mancevski B, Jakovski Z, Davceva N, Tait AR, Straus SK, Honer WG. Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia. Schizophr Res. 2009; 109(1-3):159-66.
Beasley CL, Honavar M, Everall IP, Cotter D. Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder. Schizophr Res. 2009; 115(2-3):156-62.
Pennington K, Beasley CL, Dicker P, Fagan A, English J, Pariante CM, Wait R, Dunn MJ, Cotter DR. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry. 2008; 13(12):1102-17.
Beasley CL, Honer WG, Bergmann K, Falkai P, Lütjohann D, Bayer TA. Reductions in cholesterol and synaptic markers in association cortex in mood disorders. Bipolar Disord. 2005; 7(5):449-55.
Beasley CL, Zhang ZJ, Patten I, Reynolds GP. Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins. Biol Psychiatry. 2002; 52(7):708-15.